In this article, we report on eight grand challenges for value sensitive design, which were developed at a one-week workshop, Value Sensitive Design: Charting the Next Decade, Lorentz Center, Leiden, The Netherlands, November 14–18, 2016. A grand challenge is a substantial problem, opportunity, or question that motives sustained research and design activity. The eight grand challenges are: (1) Accounting for Power, (2) Evaluating Value Sensitive Design, (3) Framing and Prioritizing Values, (4) Professional and Industry Appropriation, (5) Tech policy, (6) Values and Human Emotions, (7) Value Sensitive Design and Intelligent Algorithms, and (8) Value Tensions. Each grand challenge consists of a discussion of its importance and a set of tractable key questions.